AMOEBA (EPA:ALMIB) - AMOEBA announces that its active substance has an eliciting action on the vine and a direct action on the germination of grape downy mildew.

Transparency directive : regulatory news

07/03/2019 17:40

PRESS RELEASE

AMOEBA announces that its active substance has an eliciting action on the vine
and a direct action on the germination of grape downy mildew.

Lyon (France), March 7th, 2019 - AMOEBA (FR0011051598 - AMEBA), producer of a
biological biocide capable of eliminating bacterial risk in water and human
wounds, and a biocontrol product for plant protection, announces that its
active substance, Willaertia magna C2c Maky in lysed form, has an eliciting
action on the vine and a direct action by total inhibition of the germination
of the grape downy mildew (Plasmopara viticola).

When a plant is attacked by a pathogen, receptors recognize the signals
(molecules) emitted by the pathogen, triggering a cascade of intracellular
events leading to the activation of the plant's defense systems, including the
production of hormones and antimicrobial compounds (proteins).

These signals are called elicitors. The supply of substances with eliciting
activity or SDP (Plant Protection Stimulators) is currently used in bio-control
as a means to protect crops.

Nevertheless, this strategy has varying effectiveness depending on
environmental conditions (stress of the plant, aggressor genetic, etc.).
Biocontrol products are therefore generally associated with plant protection
products that have a direct effect on the pathogenic fungus.

In order to evaluate the eliciting nature of its active substance, Amoéba, in
collaboration with Vegepolys Innovation, has carried out standardized tests in
qPFD(r) (a molecular biology technique quantifying the expression of 28 plant
defence genes by assaying transcribed RNAs). The results show an eliciting
effect as high as the reference product (COS-OGA) on PR proteins (Pathogenesis
Related proteins) that are produced by the plant to combat fungi.

At the same time, in order to verify the presence of a direct action on grape
downy mildew (Plasmopara viticola), Amoéba has carried out laboratory tests
with Staphyt. The results obtained by a reference method demonstrate a direct
effect on the pathogen with total inhibition of spore germination by contact
with the active substance.

To the Company's current knowledge, no bio-control natural substance agent
marketed to date has both an eliciting function on the vine and a direct action
to inhibit the germination of grape downy mildew.

As a reminder, the Company is currently in the trial phase for the biocontrol
application on plant protection and does not market any products. The marketing
of a plant protection product is subject to prior marketing authorization
(refer to 12 February 2019 Press Release for the main regulatory approval steps
in Europe).

"Combining a strong eliciting action on the plant and a direct action on the
pathogen with the same product is one way to finally offer the plant protection
market a bio-control agent whose efficacy in the field could be as high as
pesticides. It is an alternative that would significantly reduce the use of
conventional pesticides while protecting the farmer's yield. " explains Fabrice
Plasson, Chairman of Amoéba.

About AMOEBA:

Amoéba's ambition is to become a major player in the treatment of bacterial
risk in the fields of water, healthcare and plant protection. Our biological
solution is an alternative to chemical products widely used today. Amoéba is
currently focusing on the market of industrial cooling towers estimated at
EUR1.7Bn (1) on a global chemical biocide market for water treatment, evaluated
at EUR21Bn (2) and on the biocontrol market for plant protection estimated
globally at EUR1.6Bn (4). In the future, the Company is looking at developing
new applications such as chronic wound care, estimated at EUR 751 million (3)
in the USA. Sales of associated products with healthcare, biocides and crop
protection are subject to the Company being granted local regulatory market
authorizations. The Company is currently in a trial phase for biocidal and
plant protection applications and does not market any products.

Created in 2010, based in Chassieu (Lyon, France) with a subsidiary in Canada
and in the United States, Amoéba is quoted on the compartment C of Euronext
Paris. The Company is a member of the BPIfrance Excellence network and is
eligible for the PEA-PME SME equity savings plan setup. More information on
www.amoeba- biocide.com.

(1) : Amoéba data combined from sources: DRIRE 2013, Eurostat, ARHIA 2013
(2) : Sources combined by Amoéba from water treaters, Freedonia, Eurostat et
MarketsandMarkets
(3): BCC Research, "Markets for Advanced Wound Management Technologies,"
Wellesley, MA, 2017
(4): Biopesticides Worldwide Market 2013, CPL, Wallingford, UK

Contacts :

Amoéba
Valérie FILIATRE
Directeur administratif et Financier
04 26 69 16 00
valerie.filiatre@amoeba-biocide.com

Actifin
Ghislaine GASPARETTO
Communication financière
01 56 88 11 11
ggasparetto@actifin.fr

Disclaimer

This press release contains certain forward-looking statements concerning
AMOEBA which are based on its own assumptions and hypothesis and on information
that are available to us. However, AMOEBA gives no assurance that the estimates
contained in such forward-looking statements will be verified, which estimates
are subject to numerous risks including the risks set forth in the reference
document of AMOEBA filed with the French Financial Markets Authority (Autorité
des Marchés Financiers) on April 27, 2018 (a copy of which is available on
www.amoeba-biocide.com). The forward-looking statements contained in this press
release are also subject to risks not yet known to AMOEBA or not currently
considered material by AMOEBA. The occurrence of all or part of such risks
could cause actual results, financial conditions, performance or achievements
of AMOEBA to be materially different from such forward-looking statements.

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AMOEBA (EPA:ALMIB) - AMOEBA announces that its active substance has an eliciting action on the vine and a direct action on the germination of grape downy mildew.

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